LAMINATE by Sentinel
LAMINATE brings single timepoint analysis, longitudinal analysis and interactive review together for multiple sclerosis MRI research: analyse a session, compare it with a follow-up, and review every lesion in one place.
For researchers, hospitals and imaging teams. Research and educational use; not FDA-approved.
a real screen, not a mock-up
FLAIR and SWI become a FLAIR* image, with optional AI lesion segmentation.
Every lesion labelled new, growing, shrinking, static or gone.
Keep, reject and correct each lesion, then generate the report.
From a single scan to the bigger picture
LAMINATE brings lesion analysis and review into the same workflow, whether you are exploring one MRI session or following changes across sessions.
FLAIRSWIbecomeFLAIR*
From one session. Veins within lesions become easier to see, with optional AI lesion segmentation to review.
segmentation is optional, per analysis
Compare a baseline and a follow-up session of the same subject. Each lesion is labelled new, growing, shrinking, static or gone, with lesion count, volume and percent change in lesion load.
each new lesion, before and after
Step through lesions, keep or reject each one, and correct lesion masks. Edits save automatically with a version history. LAMINATE supports the review while human interpretation stays part of the workflow.
From scanner to report
Studies reach LAMINATE from your PACS through an on-site gateway, or as an archive you upload. Either way the result is the same workspace.
Studies leave over DICOM, or you upload a DICOM archive in the browser.
Patient identifiers are replaced before anything leaves your network.
Single timepoint on one session, or longitudinal on two, on GPU servers.
Step through lesions in the viewer: keep, reject, correct, score.
View it, download HTML or save a PDF. Single timepoint results can return to PACS.
the gateway runs at your site
Archives uploaded in the browser are de-identified when they are ingested. Data in the cloud is pseudonymized, not anonymous.
A connected review experience
Move from the changes between sessions to lesion-by-lesion review and the report. The images and the numbers stay in context.
Switch between baseline and follow-up, with each lesion outlined in all three planes and labelled new, growing, shrinking, static or gone.
In practice
Upload DICOM archives into a workspace, run single timepoint analyses, and score each lesion for central vein sign and paramagnetic rim in the viewer.
Connect your PACS through the on-site gateway. When a baseline and a follow-up arrive together, a longitudinal analysis can start on its own, ready to review lesion by lesion.
NYU Abu Dhabi and three Abu Dhabi clinics are putting AI-powered MRI analysis to the test for MS diagnosis, using the central vein sign to tell MS lesions apart.
Amr Bassam Shadid · 8 October 2026 · 2 min read
In a feature for Middle East Health, Dr Osama Abdullah explains how the LAMINATE study uses MRI to follow multiple sclerosis in a faster, more standardised way.
Amr Bassam Shadid · 19 May 2025 · 2 min readChoose the setting that fits
Start on the web. Add an on-site gateway when studies should flow from your PACS. Need LAMINATE inside your own environment? Talk to us.
Sign in on the web to upload studies, run analyses and review the results.
See the web workspace in a demo.Patient identifiers are replaced at your site
A small container at your site receives studies over DICOM, replaces patient identifiers before anything leaves your network, and can send results back.
Setup agreed with your IT team.The right setup starts with a conversation.
Bring your review process and organizational requirements.Before we meet
Have a question specific to your team?
Bring it to the demo.
LAMINATE is Sentinel Cloud Service’s web platform for analysing brain MRI in multiple sclerosis research. Single timepoint analysis, longitudinal analysis and interactive review are parts of one product, in one workspace.
Single timepoint analysis needs one MRI session with a FLAIR and an SWI series. Longitudinal analysis needs two sessions of the same subject, each with a FLAIR and a T1-weighted series. Studies come in as DICOM, either as an uploaded archive or through the on-site gateway connected to your PACS.
Yes. Longitudinal analysis compares a baseline and a follow-up session and labels each lesion as new, growing, shrinking, static or gone. It compares two sessions at a time; trends across several visits are not part of LAMINATE yet.
Yes. In the viewers you step through lesions, keep or reject them and correct lesion masks, and for single timepoint analysis you score central vein sign and paramagnetic rim by hand. Edits save automatically with a version history. Review stays with your team: LAMINATE does not make a diagnosis.
Studies that arrive through the on-site gateway have patient identifiers replaced before anything leaves your network, and the original identity stays with you. Uploaded archives are de-identified when they are ingested. Data in the cloud is pseudonymized rather than anonymous, and text burned into image pixels is not removed, so scanners should be configured accordingly.
No. LAMINATE is intended for research and educational use. It is not FDA-approved and should not be used for clinical diagnosis, treatment decisions or patient care.